Loren D. Walensky: search on Z-Library

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1

Distinct BimBH3 (BimSAHB) Stapled Peptides for Structural and Cellular Studies

Bird, Greg H., Gavathiotis, Evripidis, LaBelle, James L., Katz, Samuel G., Walensky, Loren D.

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 4.07 MB

english, 2014

2

Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies

Bird, Gregory H, Irimia, Adriana, Ofek, Gilad, Kwong, Peter D, Wilson, Ian A, Walensky, Loren D

Journal:

Nature Structural and Molecular Biology

Year:

2014

Language:

english

File:

PDF, 2.03 MB

english, 2014

3

SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2

Kim, Kimberly H, Kim, Woojin, Howard, Thomas P, Vazquez, Francisca, Tsherniak, Aviad, Wu, Jennifer N, Wang, Weishan, Haswell, Jeffrey R, Walensky, Loren D, Hahn, William C, Orkin, Stuart H, Roberts, C

Journal:

Nature Medicine

Year:

2015

Language:

english

File:

PDF, 2.29 MB

english, 2015

4

Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice

Mourtada, Rida, Herce, Henry D., Yin, Daniel J., Moroco, Jamie A., Wales, Thomas E., Engen, John R., Walensky, Loren D.

Journal:

Nature Biotechnology

Year:

2019

Language:

english

File:

PDF, 4.55 MB

english, 2019

5

Photoreactive Stapled BH3 Peptides to Dissect the BCL-2 Family Interactome

Craig R. Braun, Julian Mintseris, Evripidis Gavathiotis, Gregory H. Bird, Steven P. Gygi, Loren D. Walensky

Journal:

Chemistry & Biology

Year:

2010

Language:

english

File:

PDF, 1.55 MB

english, 2010

6

Synthesis of 10-Substituted “Open-Chain” Analogues of 5,10-Dideaza-5,6,7,8-tetrahydrofolic Acid (DDATHF, Lometrexol)

Edward C. Taylor, Thomas H. Schrader, Loren D. Walensky

Journal:

Year:

1992

Language:

english

File:

PDF, 1.15 MB

english, 1992

7

Management of an anaphylactoid reaction to methotrexate with a stepwise graded challenge

Andrew J. MacGinnitie, Loren D. Walensky, Stuart E. Turvey, Jordan S. Orange, Francisco A. Bonilla, Lewis B. Silverman, Hans Oettgen

Journal:

Pediatric Allergy and Immunology

Year:

2003

Language:

english

File:

PDF, 69 KB

english, 2003

8

Distinct distribution of specific members of protein 4.1 gene family in the mouse nephron

Ramez, Mohamed, Blot-Chabaud, Marcel, Cluzeaud, Françoise, Chanan, Sumita, Patterson, Michael, Walensky, Loren D, Marfatia, Shirin, Baines, Anthony J, Chasis, Joel A, Conboy, John G, Mohandas, Narla,

Journal:

Kidney International

Year:

2003

Language:

english

File:

PDF, 5.90 MB

english, 2003

9

Characterization of a core fragment of the rhesus monkey TRIM5α protein

Alak K Kar, Youdong Mao, Gregory Bird, Loren Walensky, Joseph Sodroski

Journal:

BMC Biochemistry

Year:

2011

Language:

english

File:

PDF, 3.47 MB

english, 2011

10

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

Stewart, Michelle L, Fire, Emiko, Keating, Amy E, Walensky, Loren D

Journal:

Nature Chemical Biology

Year:

2010

Language:

english

File:

PDF, 1.11 MB

english, 2010

11

Dual role of proapoptotic BAD in insulin secretion and beta cell survival

Danial, Nika N, Walensky, Loren D, Zhang, Chen-Yu, Choi, Cheol Soo, Fisher, Jill K, Molina, Anthony J A, Datta, Sandeep Robert, Pitter, Kenneth L, Bird, Gregory H, Wikstrom, Jakob D

Journal:

Nature Medicine

Year:

2008

Language:

english

File:

PDF, 714 KB

english, 2008

12

Direct and selective small-molecule activation of proapoptotic BAX

Gavathiotis, Evripidis, Reyna, Denis E, Bellairs, Joseph A, Leshchiner, Elizaveta S, Walensky, Loren D

Journal:

Nature Chemical Biology

Year:

2012

Language:

english

File:

PDF, 1007 KB

english, 2012

13

A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers

LaBelle, James L., Katz, Samuel G., Bird, Gregory H., Gavathiotis, Evripidis, Stewart, Michelle L., Lawrence, Chelsea, Fisher, Jill K., Godes, Marina, Pitter, Kenneth, Kung, Andrew L., Walensky, Loren

Journal:

Journal of Clinical Investigation

Year:

2012

Language:

english

File:

PDF, 4.30 MB

english, 2012

14

Stemming Danger with Golgified BAX

Loren D. Walensky

Journal:

Year:

2012

Language:

english

File:

PDF, 348 KB

english, 2012

15

A Stapled p53 Helix Overcomes HDMX-Mediated Suppression of p53

Federico Bernal, Mark Wade, Marina Godes, Tina N. Davis, David G. Whitehead, Andrew L. Kung, Geoffrey M. Wahl, Loren D. Walensky

Journal:

Year:

2010

Language:

english

File:

PDF, 1.19 MB

english, 2010

16

BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore

Loren D. Walensky, Evripidis Gavathiotis

Journal:

Trends in Biochemical Sciences

Year:

2011

Language:

english

File:

PDF, 1.91 MB

english, 2011

17

Neurobehavioral deficits in mice lacking the erythrocyte membrane cytoskeletal protein 4.1

Loren D. Walensky, Zheng Tao Shi, Seth Blackshaw, A.Courtney DeVries, Gregory E. Demas, Philippe Gascard, Randy J. Nelson, John G. Conboy, Edward M. Rubin, Solomon H. Snyder, Narla Mohandas

Journal:

Current Biology

Year:

1998

Language:

english

File:

PDF, 84 KB

english, 1998

18

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

Anthony Letai, Michael C. Bassik, Loren D. Walensky, Mia D. Sorcinelli, Solly Weiler, Stanley J. Korsmeyer

Journal:

Year:

2002

Language:

english

File:

PDF, 426 KB

english, 2002

19

Reactivation of the p53 Tumor Suppressor Pathway by a Stapled p53 Peptide

Tyler, Andrew F., Korsmeyer, Stanley J., Bernal, Federico, Walensky, Loren D., Verdine, Gregory L.

Journal:

Journal of the American Chemical Society

Year:

2007

Language:

english

File:

PDF, 131 KB

english, 2007

20

Four Paralogous Protein 4.1 Genes Map to Distinct Chromosomes in Mouse and Human

Luanne L. Peters, Heinz-Ulrich G. Weier, Loren D. Walensky, Solomon H. Snyder, Marilyn Parra, Narla Mohandas, John G. Conboy

Journal:

Year:

1998

Language:

english

File:

PDF, 81 KB

english, 1998

21

A Stapled BID BH3 Helix Directly Binds and Activates BAX

Loren D. Walensky, Kenneth Pitter, Joel Morash, Kyoung Joon Oh, Scott Barbuto, Jill Fisher, Eric Smith, Gregory L. Verdine, Stanley J. Korsmeyer

Journal:

Year:

2006

Language:

english

File:

PDF, 754 KB

english, 2006

22

BH3-Triggered Structural Reorganization Drives the Activation of Proapoptotic BAX

Evripidis Gavathiotis, Denis E. Reyna, Marguerite L. Davis, Gregory H. Bird, Loren D. Walensky

Journal:

Year:

2010

Language:

english

File:

PDF, 1.59 MB

english, 2010

23

A Competitive Stapled Peptide Screen Identifies a Selective Small Molecule that Overcomes MCL-1-Dependent Leukemia Cell Survival

Nicole A. Cohen, Michelle L. Stewart, Evripidis Gavathiotis, Jared L. Tepper, Susanne R. Bruekner, Brian Koss, Joseph T. Opferman, Loren D. Walensky

Journal:

Chemistry & Biology

Year:

2012

Language:

english

File:

PDF, 943 KB

english, 2012

24

Protein-protein interactions: A PUMA mechanism unfolds

Walensky, Loren D

Journal:

Nature Chemical Biology

Year:

2013

Language:

english

File:

PDF, 543 KB

english, 2013

25

Direct BAKtivation

Walensky, Loren D.

Journal:

Nature Structural and Molecular Biology

Year:

2013

Language:

english

File:

PDF, 5.37 MB

english, 2013

26

Interview: Interview with Loren D Walensky

Walensky, Loren D

Journal:

Future Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 504 KB

english, 2012

27

Targeted disruption of the EZH2–EED complex inhibits EZH2-dependent cancer

Kim, Woojin, Bird, Gregory H, Neff, Tobias, Guo, Guoji, Kerenyi, Marc A, Walensky, Loren D, Orkin, Stuart H

Journal:

Nature Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.27 MB

english, 2013

28

Multimodal Interaction with BCL-2 Family Proteins Underlies the Proapoptotic Activity of PUMA BH3

Edwards, Amanda L., Gavathiotis, Evripidis, LaBelle, James L., Braun, Craig R., Opoku-Nsiah, Kwadwo A., Bird, Gregory H., Walensky, Loren D.

Journal:

Chemistry & Biology

Year:

2013

Language:

english

File:

PDF, 1.79 MB

english, 2013

29

The 13-kD FK506 Binding Protein, FKBP13, Interacts with a Novel Homologue of the Erythrocyte Membrane Cytoskeletal Protein 4.1

Loren D. Walensky, Philippe Gascard, Michael E. Fields, Seth Blackshaw, John G. Conboy, Narla Mohandas and Solomon H. Snyder

Journal:

The Journal of Cell Biology

Year:

1998

Language:

english

File:

PDF, 2.88 MB

english, 1998

30

Inositol 1,4,5-Trisphosphate Receptors Selectively Localized to the Acrosomes of Mammalian Sperm

Loren D. Walensky and Solomon H. Snyder

Journal:

The Journal of Cell Biology

Year:

1995

Language:

english

File:

PDF, 2.65 MB

english, 1995

31

A phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activators

Szlyk, Benjamin, Braun, Craig R, Ljubicic, Sanda, Patton, Elaura, Bird, Gregory H, Osundiji, Mayowa A, Matschinsky, Franz M, Walensky, Loren D, Danial, Nika N

Journal:

Nature Structural and Molecular Biology

Year:

2013

Language:

english

File:

PDF, 961 KB

english, 2013

32

Hydrocarbon-Stapled Peptides: Principles, Practice, and Progress

Walensky, Loren D., Bird, Gregory H.

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 5.18 MB

english, 2014

33

Reactivation of the p53 Tumor Suppressor Pathway by a Stapled p53 Peptide [ J. Am. Chem. Soc. 2007 , 129 , 2456−2457].

Bernal, Federico, Tyler, Andrew F., Korsmeyer, Stanley J., Walensky, Loren D., Verdine, Gregory L.

Journal:

Journal of the American Chemical Society

Year:

2007

Language:

english

File:

PDF, 21 KB

english, 2007

34

Phospho-BAD BH3 Mimicry Protects β Cells and Restores Functional β Cell Mass in Diabetes

Ljubicic, Sanda, Polak, Klaudia, Fu, Accalia, Wiwczar, Jessica, Szlyk, Benjamin, Chang, Yigang, Alvarez-Perez, Juan C., Bird, Gregory H., Walensky, Loren D., Garcia-Ocaña, Adolfo, Danial, Nika N.

Journal:

Year:

2015

Language:

english

File:

PDF, 1.32 MB

english, 2015

35

Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices

Leshchiner, Elizaveta S., Parkhitko, Andrey, Bird, Gregory H., Luccarelli, James, Bellairs, Joseph A., Escudero, Silvia, Opoku-Nsiah, Kwadwo, Godes, Marina, Perrimon, Norbert, Walensky, Loren D.

Journal:

Proceedings of the National Academy of Sciences

Year:

2015

Language:

english

File:

PDF, 1.01 MB

english, 2015

36

Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic

Gregory H. Bird, Navid Madani, Alisa F. Perry, Amy M. Princiotto, Jeffrey G. Supko, Xiaoying He, Evripidis Gavathiotis, Joseph G. Sodroski, Loren D. Walensky and Solomon H. Snyder

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.64 MB

english, 2010

37

Playing FullBAK

Walensky, Loren D.

Journal:

Year:

2013

Language:

english

File:

PDF, 458 KB

english, 2013

38

BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress

Carpio, Marcos A., Michaud, Michael, Zhou, Wenping, Fisher, Jill K., Walensky, Loren D., Katz, Samuel G.

Journal:

Proceedings of the National Academy of Sciences

Year:

2015

Language:

english

File:

PDF, 2.03 MB

english, 2015

39

A Nonapoptotic Role for BAX and BAK in Eicosanoid Metabolism

Zhang, Tejia, Walensky, Loren D., Saghatelian, Alan

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 1.82 MB

english, 2015

40

Regulation of mitochondrial ceramide distribution by members of the BCL-2 family

Zhang, Tejia, Barclay, Lauren, Walensky, Loren D., Saghatelian, Alan

Journal:

The Journal of Lipid Research

Year:

2015

Language:

english

File:

PDF, 1.79 MB

english, 2015

41

A New Isobaric Labeling Architecture Supporting Reporter Ion Fragmentation Enables Improved Multiplexing Capacity

Braun, Craig Ronald, Bird, Gregory H., Wühr, Martin H., Erickson, Brian K, Rad, Ramin, Walensky, Loren D., Gygi, Steven P., Haas, Wilhelm

Journal:

Analytical Chemistry

Year:

2015

Language:

english

File:

PDF, 1.53 MB

english, 2015

42

Cellular Uptake and Ultrastructural Localization Underlie the Pro-apoptotic Activity of a Hydrocarbon-stapled BIM BH3 Peptide

Edwards, Amanda L., Wachter, Franziska, Lammert, Margaret, Huhn, Annissa J., Luccarelli, James, Bird, Gregory H., Walensky, Loren D.

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 5.18 MB

english, 2015

43

Reply to Fernandez-Marrero et al.: Role of BOK at the intersection of endoplasmic reticulum stress and apoptosis regulation

Carpio, Marcos A., Michaud, Michael, Zhou, Wenping, Fisher, Jill K., Walensky, Loren D., Katz, Samuel G.

Journal:

Proceedings of the National Academy of Sciences

Year:

2016

Language:

english

File:

PDF, 695 KB

english, 2016

44

Immunophilin FK506 Binding Protein Associated with Inositol 1,4,5-Trisphosphate Receptor Modulates Calcium Flux

Andrew M. Cameron, Joseph P. Steiner, David M. Sabatini, Adam I. Kaplin, Loren D. Walensky and Solomon H. Snyder

Journal:

Proceedings of the National Academy of Sciences

Year:

1995

Language:

english

File:

PDF, 892 KB

english, 1995

45

Tracking BAX once its trigger is pulled

Gavathiotis, Evripidis, Walensky, Loren D.

Journal:

Year:

2011

Language:

english

File:

PDF, 1.12 MB

english, 2011

46

Allosteric inhibition of antiapoptotic MCL-1

Lee, Susan, Wales, Thomas E, Escudero, Silvia, Cohen, Daniel T, Luccarelli, James, Gallagher, Catherine G, Cohen, Nicole A, Huhn, Annissa J, Bird, Gregory H, Engen, John R, Walensky, Loren D

Journal:

Nature Structural and Molecular Biology

Year:

2016

Language:

english

File:

PDF, 1.56 MB

english, 2016

47

Investigating the Relationship Between Helicity and Activity in Antimicrobial Peptides with Stabilized α-Helical Structures

Yuan, Amy, Mourtada, Rida, Elmore, Donald E., Walensky, Loren D.

Journal:

Biophysical Journal

Year:

2016

Language:

english

File:

PDF, 58 KB

english, 2016

48

Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices

Bird, Gregory H, Mazzola, Emanuele, Opoku-Nsiah, Kwadwo, Lammert, Margaret A, Godes, Marina, Neuberg, Donna S, Walensky, Loren D

Journal:

Nature Chemical Biology

Year:

2016

Language:

english

File:

PDF, 1.35 MB

english, 2016

49

Selective Covalent Targeting of Anti-Apoptotic BFL-1 by Cysteine-Reactive Stapled Peptide Inhibitors

Huhn, Annissa J., Guerra, Rachel M., Harvey, Edward P., Bird, Gregory H., Walensky, Loren D.

Journal:

Cell Chemical Biology

Year:

2016

Language:

english

File:

PDF, 2.12 MB

english, 2016

50

Challenges in Targeting a Basic Helix-Loop-Helix Transcription Factor with Hydrocarbon-Stapled Peptides

Edwards, Amanda L., Meijer, Dimphna H., Guerra, Rachel M., Molenaar, Remco J., Alberta, John A., Bernal, Federico, Bird, Gregory H., Stiles, Charles D., Walensky, Loren D.

Journal:

ACS Chemical Biology

Year:

2016

Language:

english

File:

PDF, 17.30 MB

english, 2016